Dutasteride (Avodart) for blocking the conversion of the hormone Testosterone

Anabolic steroids are one type of performance-enhancing drug. They mimic testosterone in the body to enhance performance by making muscle cells larger and by allowing the body to recover more quickly from the stress of exercise.
Performance-enhancing drugs are no longer just for bodybuilders or pro athletes who are willing to try illegal and potentially dangerous means to improve their body's function. These drugs are being used every day by people of all ages, from middle-school, high-school and college students to older recreational athletes.
Dutasteride (Avodart) is a dual 5-a reductase inhibitor that inhibits conversion of testosterone to DHT. It was developed to treat benign prostatic hyperplasia (BPH), which is the enlargement of the prostate. Bodybuilders have used this compound to protect themselves from hair loss.

The difference between Dutasteride and Finasteride, is in the name. Dutasteride (dual-tasteride) works on both of the 5a-reductase enzymes, while Finasteride works on just one. Dutasteride has greater efficacy because of this, and it is more powerful at a lower dose. Treating symptoms of benign prostatic hyperplasia (BPH) or enlargement of the prostate gland. It also helps to reduce the risk of urinary blockage and the need for surgery to treat BPH. It may be used alone or along with another medicine (Tamsulosin).

Dutasteride works by blocking the conversion of the hormone testosterone to the more potent hormone dihydro testosterone. It does this by blocking an enzyme called 5-alpha reductase. Dihydrotestosterone is partly responsible for making the prostate enlarge. Therefore, a reduced amount of dihydro-testosterone in the prostate causes it to shrink. This helps you to pass urine more easily.

Sometimes, more than one type of medicine is needed to control the symptoms of prostate enlargement. Dutasteride is available in combination with another medicine for prostate enlargement, called Tamsulosin. The combination brand is called Combodart and it may give quicker and better relief of symptoms than either medicine alone.

To understand how Dutasteride works we must first learn about DHT. Dihydrotestosterone (DHT) is a sex steroid and androgen hormone. The enzyme 5a-reductase synthesizes DHT in the testes, hair follicles, adrenal glands, and prostate. Reductase inhibitors work by blocking the action of the enzymes that convert testosterone to DHT. This is why they work so well for protecting/re-growing head hair and helping with BPH. Dutasteride stacked with Finasteride can lower DHT in the body up to 95%.

When bodybuilders use anabolic-androgenic steroids, it can speed up head hair loss. This is due to increased testosterone hormones in the body. The more testosterone, the more conversion to DHT in the body. In addition, running DHT derivatives such as Masteron, Winstrol or Proviron will further increase DHT. To combat this, bodybuilders have experimented with 5a-reductase inhibitors, such as dutasteride, to protect their existing hair and even re-grow more. However, this can come at a price and a myriad of side effects.

Dutasteride has been used for acne control, as it will lower an overabundance of androgens in the body. Nonetheless, it’s not a very effective anti-acne drug, and its potential side effects aren’t worth the possible acne control.

Side Effects:
Preventing sex hormone DHT from being converted from testosterone might not be the best idea in the long term. If you care about your sex drive, Dutasteride might not be for you. The two main side effects from this drug are erectile dysfunction (ED) decreased sexual desire (libido). Additional side effects like gynecomastia can occur as well, due to severely low DHT levels. Even with short term use at low dosages, some users have reported serious problems problems with ED. Therefore, the user must be extremely careful when using duta, and use it only if absolutely necessary.

A dosage of 2.5 mgs per day is a popular starting point among bodybuilders. Most guys are splitting the dose into AM/PM, but that’s not necessary. The half-life of Dutasteride is very long – up to 5 weeks. So, you can dose it EOD (every other day) or longer if you wish.

Synthetic cyclic heptapeptide Melanotan 2(MT2)

Melanotan 2(MT2) is a synthetic cyclic heptapeptide that is mainly used to increase tanning. It stimulates a natural increase in melanin production. Melanin is the main determinant of skin color in humans. Melanin is a brown pigment which causes skin to become darker in appearance when exposed to UV rays. According to scientific study that has been based on animal test subjects, the impetus of Melanotan 2’s overall functionality and mechanics can be tied to the pituitary gland. This pea-sized gland located at the bottom of the hypothalamus at the base of the brain essentially acts as the command center for the endocrine system, as it is chiefly charged with the regulation and control of several system-related functions including those related to growth, metabolism, thyroid gland function, and temperature regulation. Melanotan II’s relationship to the pituitary gland can be drilled down to a hormonal level; specifically, to hormones secreted by the pituitary gland known as melanocortins.

In essence, these particular hormones are responsible for the regulation and control of hair and skin pigmentation in an animal test subject. They achieve this measure of control by expressing melanin. The secretion of melanin is triggered by an animal test subject’s exposure to ultraviolet, or UV, rays. When the secretions are expressed, they are manifested upon the surface of the skin. This process in which this occurs is known as melanogenesis. The secretion acts as a natural means of protection against ultraviolet rays. This component, by extension, acts as a protective measure against a hot of various skin afflictions and ailments that result from prolonged exposure to ultraviolet rays. These rays include various forms of skin cancers. The primary issue with melanogenesis is the fact that the melanocortins that trigger this process has a rapid half-life that only lasts several minutes. Naturally, this means that the secretion’s overall effectiveness as a measure of protection against ultraviolet rays is very limited.

Melanotan II was first synthesized at the University of Arizona when looking at possible ways to treat skin cancer. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural pigmentary system to produce a protective tan prior to UV exposure.

Clinical trials have shown that Melanotan 2 safely promotes melanogenesis. This is a process were melanocytes produce melanin. Lighter-skinned people have low base levels of melanogenesis. Exposure to UV-B radiation causes an increased melanogenesis. The purpose of the melanogenesis is to protect the hypodermis, the layer under the skin, from the UV-B light that can damage it. It does this by absorbing all the UV-B light and blocking it from passing the skin layer.

MT2 has also been shown to have aphrodisiac effects. Giuliano F et al. showed MT2 exerting a dose-dependent effect on erections in anesthetized rats. They went on to show MT2 having inducer and facilitator activities on erection depending upon delivery route of the peptide. There are various studies showing similar results in both animals and humans. Wessells H et al. highlighted the positive effect MT2 has on sexual desire and erections in men suffering with erectile dysfunction and various organic risk factors.

Through clinical research it has been shown MT2 has excellent fat burning effects. It was previously thought that it assisted weight loss indirectly due to its appetite-reducing effect. However, it now appears that MT2 has direct fat burning effects. Strader AD et al. is a great example of the direct fat burning effect. They conducted a series of tests including one that shown MT2 treatment led to a general reduction in both visceral and subcutaneous fat tissue in high-fat-fed mice. Choi YH et al. also showed in addition to reducing food intake and inhibiting body weight gain, administration of MT2 reduces fat mass. They concluded this was most likely by accelerated lipid mobilization, but not by apoptosis (cell death).

A very interesting effect MT2 brings about is its ability to increase insulin sensitivity during researchers' trials. Heijboer AC et al studied the effects MT2 has on hepatic and whole-body insulin sensitivity. Results showed administration of MT2 increased insulin-mediated glucose disposal but did not affect the capacity of insulin to suppress EGP. MT2's acute effect on insulin sensitivity was further highlighted during studies done by the Nagoya University Graduate School of Medicine. Banno R et al.  examined the effects MT2 had on insulin sensitivity in diet-induced obese rats. The insulin tolerance test showed that insulin sensitivity was significantly improved in the MT2 group compared to the pair-fed group. Furthermore, MT2 treatment increased the number of small-sized adipocytes in epididymal white adipose tissues, suggesting that MT2 increased insulin sensitivity through action on the white adipose tissues.

Benefits of Anavar Cycle

Anavar is ideally a derivative of dihydrotestosterone (DHT). Its chemical name is 17b-hydroxy-17a-methyl-2-oxa-5a-androstane-3-one and has anabolic/androgenic ration of 322-630:24. Its molecular weight is 306.443 g/ml at the base and is written under the molecular formula C19H30O3 . Being a 17-alpha alkylated steroid and a DHT derivative, it does not aromatize into DHT when ingested in the body.

Anavar is attributed to having low anabolic as well as androgenic properties because of which its tendency to cause side effects in its users greatly diminishes. It not only helps cut extra fat from the body along with muscle development but also helps add strength to the muscles without causing any fluid deposition in the joints. The biggest advantage of Anavar is that it does not disturb the natural testosterone level of the body upon administration. In fact it is known to keep the release of other hormones in the body also restored. They primarily include FSH (Follicle Stimulating Hormone), IGF-1 (Insulin like Growth Factor 1), GH (Growth Hormone), GnRH (Gonadotropin Releasing Hormone) and LHRH (Luteinizing Hormone Releasing Hormone).

The high amount of energy released after the intake of Anavar is primarily due to stimulation of phosphocreatine synthesis in the mitochondria of the muscles. It also helps burn abdominal and visceral fat in the body at a comparatively faster rate.

Another reason that makes Anavar such a preferred drug is because it is very less toxic on the liver

Cycle 1: Dianabol and Anavar Cycle

Dianabol can either be taken alone or ingested with other anabolic steroids to produce better and improved results. Here we shall be talking about Dianabol and Anavar Cycle today. It primarily has two parts – The beginner’s cycle and the advanced cycle.

Beginners Cycle

The required quantity for this cycle is 10 mg of 100 tablets of Anavar,5 mg of 200 tablets of Dianabol and 50 g of 24 tablets of Clomid.

For the advanced cycle, the dosage should be 150 tablets of 10 mg of Anavar, 300 tablets of 5 mg of Dianabol and 36 tablets of 50 mg of Clomid.

Ideally, side effects of Dianabol are caused only if the steroid is taken in abused quantities for a very long period. Some common symptoms include high blood pressure and liver toxicity. Dianabol can be easily bought online in the form of tablets, injections and syrups with as well as without a prescription.

Cycle 2

The simplest way of taking Anavar is limiting to 50mg of Anavar a day for 8 weeks. Anavar intake should never exceed 10 weeks as the body might get immune to its effect. Some individuals, who need an extra push, can increase it up to 80 mg per day but going over that is not advised.

For best results, it works best to combine Anavar dosage with 500mg of an anabolic steroid like Equipoise for 10 weeks. To add more, one can add testosterone at the base of the cycle to get improved results. The likely dosage of the testosterone compound should not exceed 150 mg a day. This is an ideal Anavar dosage for men. In women, Anavar intake should be restricted to not more than 10 mg a day.

Unlike other strong anabolic steroids, Anavar does not cause any water retention in the joints in the cutting phases which make it comparatively less painful. It does not aromatize into estrogen when administered in the body which makes it the most preferred drug during the pre-competition purposes. Along with gain in muscle strength, Anavar is highly employed by bodybuilders the world over for quality increase in muscle tissue. It is primarily used to keep the muscle hard and tightened.

The benefits of combination - Equipoise and Testosterone

This greatly anabolic and moderately androgenic steroid has an anabolic/androgenic ratio of 100:50. It has the molecular weight of 286.4132 g/mol at base and can be detected over a interval of four to five months and has an active life of nearly 14-16 days. the chemical formula of equipoise is C19H26O and its chemical name is 1,4-androstadiene-3-one,1 7b-ol). Cheaper than Deca Durabolin, Equipoise is admired for promoting muscle mass, aggression, and corpse strength. This execution enhancing medication does not result in excess water retention and aromatization. Equipoise is also useful for improving appetite and is rated very highly as a superior bulking cycle steroid. Equipoise is as anabolic and half androgenic as Testosterone and gets converted to Dihydronandrolone (DHN), a very peaceful androgen in comparison to Dihydrotestosterone (DHT).

This anabolic androgenic steroid stimulates the release of erythropoietin in the kidneys and promotes the count of red blood cells and the percentage of red blood cells (hemoglobin and Hematocrit) that translates into greater “pumps” during intense workouts.

If that was not all, muscle mass and corpse strength gains made with Equipoise (Boldenone Undeclynate) are more pronounced than with any other steroid or performance enhancing medication. Use of this steroid, for a period of six to ten weeks, is usually associated with promotion of solid, meaty muscle fiber when complemented with intense workouts, balanced and nutritious diet, and healthy lifestyle. This steroid is second to none for providing slow but steady strength gains and trait muscle mass. Muscles gained with Equipoise (Boldenone Undeclynate) are very refined and solid.


Male athletes usually administer Equipoise in weekly dosages of 200-600mg for about 8-12 weeks while female athletes may use this steroid in weekly dosages of 50-125mg for 6-10 weeks. Post cycle remedy with Clomid and Nolvadex is highly recommended towards the close of or at the end of an anabolic steroid cycle involving Equipoise (Boldenone Undeclynate) as one of the steroids or the only steroid. Anti-aromatase inhibitors such as Cytadren or Arimidex may even be used for making Equipoise cycles more tolerable. The addition of HCG is also recommended for avoiding a “crash”, particularly when Equipoise is administered during large cycles.

The combination of Equipoise and Testosterone is considered ideal for experiencing sustaining improvements in terms of lean corpse mass. Equipoise is usually stacked with Winstrol (Stanozolol), Oxandrolone, Testosterone enanthate, Testosterone Cypionate and Testosterone Propionate.

Equipoise is best injected at least once per week for maintaining steady blood levels. Men may use Equipoise in weekly doses of 400-600mg while female athletes may use it in weekly doses of 50-150mg.When overdosed or abused, Equipoise can effect in condition complications such as deepening of voice, irregular menstrual cycles, unnatural hair growth, and unusual hair loss. Equipoise (Boldenone Undeclynate) abuse may also cause acne, increased frequency of erections, unnatural hair growth, oily epidermis, enlarging clitoris or penis. Use of this potent steroid should be stopped and medical assistance should be sought if side effects like red-colored spots on body or inside the mouth or nose, sore throat and/or fever, vomiting of blood, bone pain, nausea, sore tongue, swelling of feet or lower legs, uncommon bleeding, unusual weight gain, black/tarry/light-colored stools, dark-colored urine are experienced after using Boldenone Undeclynate. Abuse of Equipoise may even lead to negatively-artificial lipid profile, virilizing effects in women, high degree of water/salt retention, gynecomastia, increased hair growth, acne, aggravation of male pattern baldness, and sexual side effects. Athletes should always emphasize on rotating injection sites on a regular basis and must follow healthy administration practices to avoid irritation, infection, and abscess formation.

How to use Cytomel and HGH in bodybuilding

Cytomel is a thyroid hormone supplement that contains liothyronine. Liothyronine is a synthetic form of the hormone T3, which is naturally produced by the thyroid gland. This medication is given when the body does not produce enough of the hormone T3 on its own, a condition known as hypothyroidism.

Human growth hormone is naturally produced by the anterior lobe of the pituitary gland. There are HGH medications available by prescription for those with kidney failure, Turner's syndrome or other diseases. HGH medications, such as somatropin, humatrope, norditropin, are only not available in pill form, they come as injections. The DEA also states, " HGH is only bio available in the injectable form. The HGH molecule is too large for absorption across the lining of the oral mucosa and the hormone is digested by the stomach before absorption can occur."

Both Cytomel and HGH are hormones that are used for medical reasons to regulate growth in individuals whose bodies do not produce enough of these hormones naturally. When a person needs the medication Cytomel, she most likely has an underactive thyroid and she will gain weight, according to the Mayo Clinic. When a person needs an HGH medication, his body is not growing enough. Cytomel is liothyronine, a man-made medication designed to mimic the action of the T3 that is naturally produced by the thyroid gland. Somatropin is an injectable form of the HGH produced by the pituitary gland.

Cytomel up-regulates the beta-2 adrenergic receptors in fat tissues. In lipolysis, or the breakdown of fat in fat tissues, the enzyme HSL (hormone sensitive lipase) plays a significant part. HSL controls the rate of lipolysis. For HSL to be activated, epinephrine and nonepinephrine (catecholomines) are necessary. These catecholomines bind to the beta-2 receptors, and thus when Cytomel up-regulates the beta-receptors, there is a corresponding increase in the ability of catecholomines to activate HSL, resulting to increased lipolysis.

This drug is likewise known to increase the UCP-3 or uncoupling protein-3. This process significantly increases lipolysis. Further, Cytomel also stimulates growth hormone (GH) production, as substantiated by several studies. And since GH is a thermogenic, it contributes to this drug’s fat-burning action. This is why when athletes are using Cytomel they find no need to use HGH. With AAS use, the suppression occurs even after the therapy is stopped, sometimes in periods of weeks or months (especially in cases of long-term use). The same thing is observed during insulin intake, whereby the pancreas (the organ responsible for insulin production) ceases its production of insulin. Such is not the case with exogenous T3 hormone therapy. Several studies have concluded that thyroid therapy does not cause prolonged suppression of thyroid normal production. Thyroid function is normalized just days after medication is discontinued. In other words, there is no thyroid shutdown due to T3 supplementation; there is only a down-regulation of thyroid output during therapy.

Side effects of this class of drug include tachycardia and atrial arrhythmia, bone resorption, and loss of lean muscle tissue. Secondary side effects include insomnia, diarrhea, and nausea. These adverse reactions are highly possible if the user takes high dosages. Notice that some of its major side effects relate to the cardiovascular system. This is because thyroid hormones have significant effects on cardiac structures (including cardiac muscles) and systems that alter cardiovascular hemodynamics. Hyperthyroidism increases virtually all cardiac functions including heart rate and contractility, diastolic relaxation, and rate of ventricular pressure development. This results to an increased cardiac output by as much as 250 percent. These physiological changes are (most likely) the consequences of an increase in the expression of ATP and a decrease in the expression of ATP’s inhibitor, phospholamban.

Another drawback of Cytomel is its catabolic ability. When Cytomel exerts this ability on stored fats, this is an asset. However, this becomes a liability when it exerts this on bones and muscles. The negative result is bone resorption and muscle wasting (mentioned above). Moreover, this drug also diminishes GH’s nitrogen retention ability (although it stimulates GH’s production, as mentioned earlier). There is consensus among Cytomel users that the dosage protocol with this drug is to ramp it up, which means you start at the lowest dosage then gradually move upward. However, there are divergent opinions on how long the ‘gradually’ part should be. There are those who say it should be every three days, and then some pharmacological studies endorse it from 1 to 2 weeks. However, the user’s tolerance level ultimately determines the time frame; that is, if the user reacts really well with Cytomel, then the dosage can gradually increase every three days. Users are advised not to ramp up and down the dosage during therapy as this causes fluctuations in hormone levels, which further results to hormonal imbalance. The more prudent practice is to taper off the dosage. The minimum daily dosage of T3 is 5mcg and the maximum is 100mcg.

Cytomel intake is not dependent on body weight or gender, but rather on the individual’s blood level. This means that females can take the same dosage volume and schedule as males.

Trenbolone - powerful anabolic steroid

Trenbolone is a very powerful steroid that has never been FDA approved for use in humans. However over time bodybuilders have realized its unique properties and powerful benefits and it has become a favourite anabolic steroid for many, despite having more harsh side effects than most other steroids. Many people would convert the pellets into an injectable form, in a rather crude and dangerous manner that would neither be safe nor sterile, and poses many risks.

Trenbolone is a highly androgenic steroid, with binding to the Androgen Receptor (AR) in the region of three times as high as testosterone. It does not aromatise and so is not subject to estrogenic side effects. In addition to high androgenicity, it is also extremely anabolic too, thus is very good at building muscle mass, and retaining muscle mass in a calorie deficient mode. It is also thought that Trenbolone inhibits cortisol production directly through the glucocorticoid receptors. Trenbolone is often found to be a body transforming drug, and also can aid a little in fat loss. This may be due to the very strong binding of trenbolone to the AR, which has been postulated to be one mechanism that results in the activation of fat loss pathways, possible through direct binding to fat cells' ARs. This makes Trenbolone a favourite among bodybuilders for cutting, and in addition to these benefits, Trenbolone usually results in large increases in strength due to its high androgenic effects.

Trenbolone although not converted to estrogen, does have progesterone effects, which will be discussed further in the side effects section of this article.

Suggested Cycles / Uses
Typically today underground labs produce Trenbolone acetate (GP Tren Acetate) as 75g/ml or 100mg/ml. It is often recommended first-time users of Trenbolone to use the faster acting acetate in case the side effects become too much for the user, they can then come off of the steroid very quickly and it is out of the system much quicker than, for example, the enanthate ester. For the novice user, 75mg or 100mg every other day is advised, however due to the acetate ester being even shorter than a propionate ester and the half life 1 day or less, to both reduce sides and aid gains, it is advisable that the user (if they can bear every day injections) injects Trenbolone acetate (GP Tren Acetate) every day (ed), at 37.5-50mg ed.

More advanced users may find that taking the Trenbolone to amounts over 500mg per week has very desirable effects on strength and body composition, however note that the side effects will also increase with the increase in dose. Due to the negative effect that Trenbolone has on libido, it is not generally recommended to take trenbolone without testosterone. However, one can take trenbolone for short periods without testosterone and introduce an aid such as Proviron (Metsterolone) to help with the libido issues, along with proper extensive post cycle therapy (PCT) for recovery. A typical test-free cycle with trenbolone may include something like 600mg Primobolan per week, 400mg trenbolone enanthate per week, for 10 weeks, PCT starting 2 weeks after last injections. The enanthate ester and other similar esters of Trenbolone can be injected twice per week. Below are some example cycles using Trenbolone:

Novice:
Testosterone propionate 100-150mg eod, 6-8weeks
Trenbolone acetate (GP Tren Acetate) 75-100mg eod, 6-8 weeks, PCT 4 days after last prop injection.

Intermediate:
Testosterone enanthate 750mg per week, weeks 1-12
Trenbolone enanthate 400mg per week, weeks 1-12
Winstrol 50mg ed weeks, 8-14

Primobolan 600mg per week, weeks 1-10
Testosterone propionate 200mg eod weeks 1-12
Trenbolone enanthate 400mg per week, weeks 1-10

Advanced:
Primobolan 600mg per week, weeks 1-10
Trenbolone enanthate 400mg per week, weeks 1-10
Testosterone enanthate 1000mg per week, weeks 1-12
Trenbolone enanthate 500-700mg per week, weeks 1-12
Anavar 80-100mg ed, weeks 1-14

Very advanced/pre-contest:
Testosterone propionate 100-200mg ed
Trenbolone acetate 75-100mg ed
Masteron 400-600mg per week
Winstrol 50mg ed
Primobolan 600mg per week
Halotestin 10-20mg ed

Trenbolone (GP Tren Acetate) is the one that should be used with extreme caution and only after plenty of research into its side effects and common cycles have been carried out. Trenbolone side effects can be very bad to many users, so much so that they will not use it despite its very positive effects on the body and strength. Firstly, as Trenbolone is so androgenic, all side effects that are seen with strong androgen's can be expected (if prone) with Trenbolone. If one is prone to male pattern baldness (MPB) than Trenbolone will likely speed this up. Some users find acne on Trenbolone worse than when on any other steroid. Certainly Trenbolone is not recommended for female users due to its strong androgenic properties and the common side effects that manifest themselves in females who use strong androgens.

Despite the fact that Trenbolone cannot aromatise, due to the progesterone route it can cause things like gynecomastia, but this will only really happen in the presence of estrogen. This does happen though in many users, as Trenbolone is usually stacked with a testosterone, which obviously can and will convert to estrogen. Gynecomastia from Trenbolone can be quite bad many will find, however if you do not suffer from this than other estrogen side effects should not be of worry, as Trenbolone does not cause any water retention or similar, but in fact often gives a hardened look and feel to the muscles.

Trenbolone also seems to give many users poor sleep patterns and insomnia. In addition, it can cause severe sweating in many, both during the night time and also just from doing the smallest of activities such as walking up stairs, etc. It also can impair to a certain degree, cardiovascular function, which means that it is not ideal for use in those who regular partake in such sports or activity that require a decent level of cardiovascular fitness.

Trenbolone also increases blood pressure in many users, some to such a degree that they have to cease using it. Thus it is recommended that one who wishes to use trenbolone, invests in a blood pressure monitor so they can regularly measure their blood pressure and keep an eye on it throughout the cycle.

Many people claim that Trenbolone has a negative effect on the kidneys. There are many of these claims certainly across the Internet since its use has become more widespread. However, there is no real evidence for these claims, and certainly many long-term users of Trenbolone have kidney function tests that are well within the normal range. Perhaps the reason for this theory is the fact that when using Trenbolone, many find that their urine can become a much darker more orange-brown colour. However, this is due to the fact that Trenbolone undergoes very little modification or breakdown and is excreted as a rust-colored oxidised form in the urine. In addition to this, any damage to kidney may not even be directly due to the Trenbolone, but more to do with the increased sweating and water loss from excessive body heat whilst on Trenbolone, without the sufficient addition of water intake. Thus it is recommended if running Trenbolone to keep the water intake high.

As Trenbolone is such a strong steroid, it is very harsh on the HTPA axis and will shut down the body's natural testosterone production very easily and, for many, very harshly. It is comparable that people can experience with Deca, and longer cycles may need to include the use of HCG to restore one's own natural production of testosterone. Recovery from cycles containing Trenbolone is not easy, and requires a very well thought out and stringent PCT routine and diet.

It has also been suggested through research that Trenbolone actually (although aiding slightly in fat loss) reduces endogenous T3 levels. Thus some advocate the use of 25mcg T3 throughout a Trenbolone cycle.

Dianabol and use in bodybuilding

Dianabol, an orally-effective anabolic steroid. An extremely popular steroid among athletes and bodybuilders, this performance enhancing drug is readily available without a prescription in many countries.

Dianabol has the ability of stimulating dramatic and nearly-permanent improvements in terms of muscle strength, muscle function and size, glycogenolysis, and protein synthesis. This anabolic androgenic steroid can easily pass through the liver and only a small part of this steroid gets broken down because of 17α-methylation of Dianabol. This means Dbol can even be used by athletes who are prone to liver toxicity when using oral steroids.

This steroid has been extremely popular among amateur and professional

bodybuilders and some of the most eminent names to have accepted its use include Arnold Schwarzenegger, Ronnie Coleman and Phil Heath. Dianabol is best used at the start of a steroid cycle to kick start gains and may even be used as a bridge between steroid cycles for maintaining muscle mass and body strength gains.
Dianabol is a fast-acting anabolic steroid which works quickly and quite effectively on the body. Depending upon the desired effects, athletes, weightlifters and power lifters will have a wide dosage range with Dianabol.  The daily dose range, depending upon the individual can range anywhere from 2-20 tablets per day, though an effective dose for athletes would be around 15-40 mg per day. One reason that Dianabol is preferred for use in athletes is because of the medications ability to reduce endogenous cortisone levels by as much as 50-70%, which slows the rate of protein breakdown in the muscles.

This steroid is rated a better option (gram for gram) than Testosterone as Dianabol minimizes affinity of the steroid for sex hormone binding globulin, which is a protein deactivating steroid molecules and capable of inhibiting them from further reactions in the body. In addition to this, Dianabol remains the favorite choice among power lifters and bodybuilders as it helps them increase repetitions during intense workouts and reduces workout fatigue to a significant extent. This steroid also has the ability to promote the sense of well being and sleep patterns. Dianabol use is also associated with the promotion of calcium deposits in the bones, improving bone strength, and enhancing muscle density while improving endurance capacity.

Recommended Dose Of Dianabol:
Male athletes usually use Dianabol in doses of 25-50mg every day while female athletes prefer using Dianabol in doses of 10-20mg every day. Dbol is ideally stacked with Primobolan, Deca Durabolin, Trenbolone Acetate, Testosterone enanthate or propionate and Deca Durabolin. Athletes administered with Dianabol should always emphasize on post cycle therapy with Clomid and Nolvadex. This is important for restoring the production of natural testosterone in the body and preventing excess estrogen formation that could have resulted in estrogenic side effects like oily skin, gynecomastia, and acne.

Dianabol is not recommended to those diagnosed with health conditions such as hypertension, high blood pressure, and prostate or breast cancer. It is also not advised to those diagnosed with health conditions such as testicular atrophy, testicular cancer, liver damage, kidney damage, stroke, or respiratory problems. It is also not recommended for children and girls and women, especially those who are pregnant, breastfeeding, or who may get pregnant while using it. Dianabol is also not advised to those who are allergic to it's ingredients.

This potent anabolic steroid should not be overdosed in hopes of quick benefits. The use of Dianabol over extended periods of time should always be avoided as it may lead to liver damage in case of qualified knowledge or lack of appropriate care. Moreover, it should always be purchased from a reputed steroid pharmacy with a valid medical prescription. Abuse or overdosing or use of low grade Dianabol can lead to side effects like male pattern baldness, clitoral hypertrophy, oily skin bouts, and insomnia or difficulty when urinating, edema (swelling), increased aggression, fever, or pain in the lower back (particularly in the kidney areas), and high blood pressure. Dianabol capsules, pills, or injections should be discarded by taking the advice of a pharmacist or local waste disposal company in case they are not to be used any more or expired.

Dianabol has both strong anabolic and androgenic action which means a noticeable increase in strength, force and muscle mass.  With the medication users can expect an increase of 1-2 kg of weight per week, which during the first 6 weeks of usage is normal. With the dosage of Dianabol being varied, particularly among trainees, weight lifters and athletes, the medication dosage may fluctuate between 2-10 pills per day and in some cases higher.  The effects on weightlifters can be most noticed at a dosage between 15-40 mg per day.

For the beginning weight trainer, the dose should never be higher than 15-25 mg per day, this dosage is effective to yield noticeable results within an 8-10 week continuous cycle.  If the steroidal effects of Dianabol are decreased after an 8-week cycle, the medication can be used in conjunction with another injectable steroid, but the dose does not need to be increased.

For a weightlifter, good results can be obtained at a dosage of 20-30 mg per day of Dianabol combined with an additional 200-400 mg dose of Deca-Durabolin weekly.  For those who seek a strength increase and muscular definition, combing Dianabol with Oxandrolone or Winstrol, will yield desirable results.

Dianabol is not recommended for competition weight training because it causes significant water retention.  Women who wish to use Dianabol can experience desirable results at a dosage of 10-20 mg per day.  For women who do not experience any adverse side effects from using Dianabol, a dosage of 2-4 pastilles a day for a period of 4-6 weeks can be ideal.Though Dianabol has many adverse side effects, but are rare for athletes who take a dose of 20 mg per day.  The main side long-term side effect of Dianabol is liver damage, which can be experienced at both high and low doses.

Dianabol: Cycle
Dianabol has an active life of between 6-8 hours, with a half-life of around 3-4 hours.  A single daily dose of Dianabol will produce a varying blood level, with fluctuations experienced throughout the day.  A person can take a dose in whole form or split up the tablets during the day, by dividing up the dose the user will be better able to control blood concentration levels. An average dose of Dianabol for males is between 15-50 mg per day and for women between 5-10 mg per day. Being the preferable steroid for men, even a moderate amount of Dianabol will result in extreme masculinizing characteristics in women.

T3 and T4 - the two effective thyroid hormones

Hypothyroidism is a condition classified by an under-active thyroid gland—when the thyroid does not produce enough hormones. There are various treatments available, but the basic concept is the same—and it's known as thyroid hormone replacement therapy.
To best understand the purpose of thyroid hormone replacement therapy, you need to understand the interaction of T3 and T4—the two thyroid hormones. Both the thyroid and parathyroid glands are endocrine glands. This means they make and secrete (release) hormones. Hormones are chemicals which can be released into the bloodstream. They act as messengers, affecting cells and tissues in distant parts of your body. Thyroid hormones affect the body's metabolic rate and the levels of certain minerals in the blood. The hormone produced by the parathyroid also helps to control the amount of these essential minerals.

The full name of T3 is Triiodothyronine and T4's full name is Tetraiodothyronine or Thyroxine. T3 and T4 control your body's metabolism. If you don't have enough of them, then your metabolism slows down. Your metabolic rate dictates how quickly you process food, how fast your heart beats, how much heat your body creates—and even how quickly you can think. In essence, T3 and T4 are in charge of how your body uses energy.

T3 and T4 are not equal in strength; T3 is the more active hormone of the two. While T3 is stronger, taking synthetic T4 hormone is considered the standard treatment for hypothyroidism. The reason for this is because most of the T3 in our bodies actually used to be T4. When T4 hormones come into contact with other cells in the bloodstream, they give up an iodine atom to interact with those cells. When T4 loses an iodine atom, it becomes T3.

When this T4 into T3 conversion occurs, T3 then conveys the metabolic "message" to the other cells throughout the body. The benefit of taking only T4 therapy is that you're allowing your body to perform some of the actions it is meant to do, which is taking T4 and changing it into T3. The half life of T4 is also longer compared to T3 (7 days versus 24 hours), that means that it will stay for a longer time in your body after ingestion.

The thyroid makes three hormones that it secretes into the bloodstream. Two of these hormones, called Thyroxine (T4) and Triiodothyronine (T3), increase your body's metabolic rate. Essentially, the body's metabolic rate is how quickly the cells in your body use the energy stored within them. Thyroid hormones make cells use more energy. By controlling how much energy our cells use, thyroid hormones also help to regulate our body temperature. Heat is released when energy is used, increasing our body temperature. Thyroid hormones also play a role in making proteins, the building blocks of the body's cells. They also increase the use of the body's fat and glucose stores.

In order to make T3 and T4, the thyroid gland needs iodine, a substance found in the food we eat. T4 is called this because it contains four atoms of iodine. T3 contains three atoms of iodine. In the cells and tissues of the body most T4 is converted to T3. T3 is the more active hormone, it influences the activity of all the cells and tissues of your body.

The other hormone that the thyroid makes is called calcitonin. This helps to control the levels of calcium and phosphorus in the blood. These minerals are needed, among other things, to keep bones strong and healthy. Your thyroid gland is a small gland, normally weighing less than one ounce, located in the front of the neck. It is made up of two halves, called lobes, that lie along the windpipe (trachea) and are joined together by a narrow band of thyroid tissue, known as the isthmus. The function of the thyroid gland is to take iodine, found in many foods, and convert it into thyroid hormones: Thyroxine (T4) and Triiodothyronine (T3). Thyroid cells are the only cells in the body which can absorb iodine. These cells combine iodine and the amino acid tyrosine to make T3 and T4. T3 and T4 are then released into the blood stream and are transported throughout the body where they control metabolism (conversion of oxygen and calories to energy).

Every cell in the body depends upon thyroid hormones for regulation of their metabolism. The normal thyroid gland produces about 80% T4 and about 20% T3, however, T3 possesses about four times the hormone "strength" as T4. The thyroid gland is under the control of the pituitary gland, a small gland the size of a peanut at the base of the brain (shown here in orange). When the level of thyroid hormones (T3 and T4) drops too low, the pituitary gland produces Thyroid Stimulating Hormone (TSH) which stimulates the thyroid gland to produce more hormones. Under the influence of TSH, the thyroid will manufacture and secrete T3 and T4 thereby raising their blood levels. The pituitary senses this and responds by decreasing its TSH production. One can imagine the thyroid gland as a furnace and the pituitary gland as the thermostat.

The pituitary gland itself is regulated by another gland, known as the hypothalamus (shown in the picture above in light blue). The hypothalamus is part of the brain and produces TSH Releasing Hormone (TRH) which tells the pituitary gland to stimulate the thyroid gland (release TSH). One might imagine the hypothalamus as the person who regulates the thermostat since it tells the pituitary gland at what level the thyroid should be set.

Treatment of hypothyroidism:
After proper diagnosis of hypothyroidism, the next issue is with what substance to treat. The traditional approach is to use Synthroid/ Levoxyl/Levothroid (levothyroxine) which is only T4. Natural medicine doctors tend to use Armour thyroid which is a mixture of mono and di-iodothryonine and T3 and T4, the entire range of thyroid hormones.

If the Free T3 level is significantly lower than the Free T4 level, it is next to useless to treat with Synthroid/ Levoxyl/Levothroid (T4) only replacements. If the patient could not muster sufficient T3 from their gland (which produces some T3 directly), then they are certainly not going to convert enough T3 from T4 only. Traditional medicine assumes that preparations like Synthroid which are T4 only converts peripherally in the body to T3 in fairly standard amounts and at fairly standard rates. Unfortunately, clinical experience shows this is not true for the majority of patients. Consistent measuring of both free T3 and free T4 blood levels in hypothyroid patients who are on T4 only therapy will very rapidly dispel this myth. A certain percentage of hypothyroid patients do convert enough T4 to T3 at a sufficient rate for T4 treatment to be adequate as a source of T3; but a substantial proportion of patients require some combination of both exogenous T3 and T4.

Once on hormone replacement, the TSH remains useful until it goes BELOW 0.4. Then one has optimized thyroid function by the TSH yardstick; it then remains to optimize thyroid function by the yardstick of the accurate measures of the 2 thyroid hormones, the Free T4 and Free T3 levels.

So one should use a combination of T4 and T3 which compensates for the inability to convert T4 to T3. This is most frequently done with Armour thyroid. However, Cytomel, which is T3 only, can be used in combination with one of the T4 only preparations. It is important to recognize that T3 should always be prescribed twice daily due to its shorter half life. This is typically after breakfast AND supper for compliance reasons.

Taking the dose at these times overcomes traditional medicine's major objection and resistance to using natural thyroid preparations - its variability in its blood levels. Armour thyroid is desiccated thyroid and has both T3 and T4. Most doctors using Armour thyroid are not aware that Armour thyroid should be used twice daily and NOT once a day. The major reason is that the T3 component has such a short half life and needs to be taken twice daily to achieve consistent blood levels.

Once or twice daily dosing one can then optimize both the T4 and T3 levels, with whatever thyroid preparation is required. This is not possible in most hypothyroid patients with T4 only preparations. It is important to use a preparation with T3 because T3 does 90% of the work of the thyroid in the body. The only exception to pursue optimization of the T3 level without using Armour thyroid is in severe acute cardio-pulmonary conditions, when the metabolic slowing effect of a low FT3 level can actually be life-saving. However, the vast majority of hypothyroid patients do not have acute cardio-pulmonary conditions, such as congestive heart failure.

The most common starting dose for patients with hypothyroidism is Armour thyroid, 90 mg which is cut in half with a razor blade and half is taken after breakfast and the other half after dinner. Taking it after meals also helps to reduce volatility of the blood-level of T3. If the patient has any problem breaking or cutting the pill, they should purchase a pill-cutter at the pharmacy. The TSH, Free T3 and Free T4 are then repeated in one month and the dose is adjusted.

In order to optimize the hormone replacement, the Free T3 and Free T4 should be above the median but below the upper end of the laboratory normal reference range. The goal for healthy young adults would be to have numbers close to the upper part of the range, and for cardiace and/or elderly patients, the numbers should be in the middle of its range. The Free T3 and Free T4 levels should be checked every month and the hormone therapy readjusted until the FT3 and FT4 levels are in the therapeutic range described. A small number of large, overweight, thyroid-resistant women may need 6-8 grains of Armour Thyroid or the equivalent of thyroxine per day (counting 0.1mg of T4 as 1 grain of Armour Thyroid). Patients need to be warned about the overdosage symptoms which are frequently only temporary during the adaptation stage. The symptoms may include: palpitations, nervousness, feeling hot and sweaty, rapid weight-loss, fine tremor, and clammy skin. There is one exception to the 1.5 level of TSH as the cutoff for treatment. Overweight patients who have classic symptoms of hypothyroidism and have made heroic unsuccessful attempts to lose weight may benefit from thyroid hormone replacement even if their TSH slightly below 1.5 and FT4 and FT3 are not below their normal ranges. Since the only change will be in the FT3 level, which has a short half-life, the serum FT4 and FT3 levels (and TSH, if indicated) can be measured 48-72 hrs after the splitting of the doses if the patient had been on the hormone for 4-6 weeks before the splitting of the doses. This is because the T4 fraction is the one that takes a number of weeks to build up to its steady-state serum level.

The classic Anadrol 50/Sustanon 250 cycle for build muscles

Anadrol 50 and Sustanon 250 are both excellent mass weight and strength gain drugs. Though each is androgenic and anabolic in nature, both have high estrogenic activity potential (though through different mechanisms). This means that each can dramatically suppress the natural testosterone production regulated by the body’s HPTA (hypothalamus-pituitary-testes-axis) system due to the negative feed-back loop caused by too much estrogen in a males body. Interestingly enough is the fact that the same estrogenic activity has a profound positive effect upon the amount of weight and strength gain an individual will realize during the administration of either or both of these drugs.

Sustanon 250 is a commonly prescribed drug for treating low testosterone levels in men (TRT). This steroid compound is used by athletes and bodybuilders to gain muscle mass and increase strength.

Also known as Dura-Testin, Sustoplex and Sustanon, this anabolic androgenic steroid is a blend of four components of Testosterone — Testosterone propionate 30 mg, Testosterone decanoate 100 mg, Testosterone phenylpropionate 60 mg, and Testosterone isocaproate 60 mg and the total amount of testosterone per mL of Sustanon is 250mg.

During testing, Sustanon 250 can be detected over a period of 2-3 months, and has an active life of approximately 2-3 weeks. Use of this steroid is also associated with development and maintenance of reproductive tissues such as prostate, epidermis, seminal vesicles, testes, and the male sexual organ even at low doses. Athletes and bodybuilders use Sustanon 250 as it improves oxygen carrying capacity of the body and promotes muscle function, muscle size,  strength, performance, stamina, and red blood cell production.

Estrogens in any form trigger glucose up-take by some tissues. In this case the tissue of interest is muscle and the result is greater levels of glycogen and water stored inside of the muscle cell. The benefits are rather obvious but bare mentioning none the less. Increased glycogen means increased fuel in the cells to make our favorite muscle gasoline called ATP (Adenosine Tri-Phosphate). This provides for an increase in training intensity and faster post-training recovery. Each gram of glycogen synthesized and stored brings with it about 3 grams of water. This adds to the cells structural integrity like putting a foundation under a house. With a stronger foundation comes a greater load capacity. Big weights and extra fuel will ultimately increase muscle mass and allow for bigger weights. One factor positively effects the other.

Anabolics increase protein synthesis in muscle tissue and androgen's aid the process while increasing training intensity. A greater weight and work-load from increased training intensity results in a greater stimulus to the trained muscles that tells it to adapt by getting stronger and bigger. However without the anabolic effect that tells the muscle fibers to grow… nothing happens. So the combination of a high androgenic drug with an anabolic substance will result in growth, but the addition of one that has estrogenic activity (by way of structure like AD-50 or aromatization like testosterones) will fuel the process at a greater rate.

Sounds great but the problem is the cycle exit and the set of raisins swinging comically down stairs post-cycle. Remember the HPTA? The excess estrogen shuts down natural testosterone production from "the boys" in a time progressive manner. This means that as the cycle or protocol continues the inhibition of the HPTA grows greater. With the resulting lack of natural androgen production post-cycle the male body finds itself in an estrogen dominant environment that in itself destroys male attributes. Yes, this does include the newly acquired muscle mass as well.

The Anadrol 50 and Sustanon 250 stack will result in a rapid weight and strength gains that will be lost post-cycle due to HPTA shut-down. Sustanon has about a 21 day active-life. But since it is made up of 4 different testosterone esters, each with different active-lifes, the period of build-up and decline of actual testosterone in the circulatory system requires an administration schedule intended to allow for this. In short, as one begins to run out the next replaces it after the dosage peaks. AD-50 has an active-life of less than 16 hours so it is easily scheduled to act as a replacement androgen for the shorter acting testosterone esters in Sustanon. The result is a fairly stable androgen activity level and the ability to keep the HPTA functioning nearer to normal. Additionally this allows for improved post-cycle lean mass retention if an athlete continues to train and eat properly. There has of course been better choices for this type of protocol and the specific intended application bares a reason for discussion as well.

Ingredients:
100 tabs of Anadrol 50 mg, 14 x 2 ml Sustanon 250 mg, 4 x 1 ml vial of HCG 5000 u.i., 40 tabs of Nolvadex 20 mg.

This is the classic Anadrol/Test stack. If you are looking for sheer mass, you are not going to find a better mix. Be warned though, estrogenic side effects are likely to be intense. A super cycle for mass building with strong anabolics like Anadrol and Sustanon. A cycle resulting in the highest mass gains and stronger androgen properties

Powerful anabolic steroid Drostanolone Propionate

Masteron is a modified form of Dihydrotestosterone, with a methyl group at the 2nd carbon (carbon alpha) atom. This modification is responsible for the anabolic strength increase. This methyl group makes it harder for the enzyme 3-hydroxysteroid dehydrogenase to metabolize Masteron. This enzyme is abundantly present in muscle tissue, and is responsible for degrading any DHT into two inactive metabolites: 3-Alpha Androstanediol and 3-Beta Androstanediol. Because of this enzyme DHT is not anabolic in muscle tissue at all. It is believed that if the enzyme 3-hydroxysteroid dehydrogenase was neutralized, DHT would actually be a very powerful anabolic steroid. Drostanolone's methyl group addition makes it imune to this enzyme. 

Drostanolone is injected into the body as an ester (bonded to either Propionate or Enanthate). Enzymes cleave off the ester from the Masteron molecule - which takes varying amount of time depending on which ester was used. This process causes the gradual release rate and extended half-life of the steroid. Drostanolone Propionate has a half-life of 2.5 days, while Drostanolone Enanthate has a half-life of 10 days. 

Intended use of Drostanolone / Masteron:  
Masteron was initially marketed as a treatment of female breast cancer. Because it pronounced male characteristics in women and because more effective breast cancer treatments were invented, Drostanolone was gradually phased out.

Actual use of Masteron:
Nowadays Drostanolone is a very popular anabolic steroid used mainly by athletes and bodybuilders.

Like other steroids Masteron can be injected into any muscle (if the muscle is big enough). The most popular being buttocks, shoulders and triceps. 

Masteron cycle compatibility, examples and duration 

Like majority of steroids, Masteron acts very well in combination with Human Growth Hormone (4IU per day). 

Effects of Drostanolone / Masteron (desirable) 

There are principally two desirable effects of Testosterone: 
physical / athletic performance enhancement (endurance, strength, faster regeneration)  physique enhancement (muscle buildup, fat loss)
The rest of desirable testosterone effects that an individual might experience during the steroid cycle, include:  increase in collagen synthesis and bone mineral content. Collagen is the protein-based construction material for connective tissues throughout the body (the ligaments, tendons, cartilage, joints, and bones).

Masterone or Drostanolone is an anabolic androgenic steroid that has been successfully used as a breast cancer drug. This anabolic androgenic steroid is commonly used by athletes who want to retain strength and muscle mass while losing fat. Also used in the bodybuilding community as a muscle defining drug and diuretic, this steroid can increase muscle hardness and density in a short period of time to give a more complete appearance to users, when preparing for bodybuilding contests. 

Masteron is available in two forms: Masteron propionate and Masteron enanthate. The primary difference between these two is that while the enanthate version is slow but long acting, the propionate version is fast and is required to be injected every other day.

Masteron propionate (or Drostanolone propionate) is perhaps one of the more "exotic" anabolic androgenic steroids in today's online market. It can be purchased, with or without a medical prescription, in different forms like capsules, tablets, sprays, or injections. Masteron propionate has a half life of 1-2 days.

Commonly used as a cutting or pre-contest drug, its use is associated with improvements in terms of aggression, performance, stamina, muscle size, and muscle function. This derivative of Dihydrotestosterone (DHT) blocks the conversion of free testosterone to estrogen by the aromatization pathway by inhibiting the aromatase enzyme. As a result, Masteron marginally increases the amounts of active free testosterone in circulation and negate the side effects of high estrogen levels because of aromatization.

One of the biggest advantages associated with use of this steroid is that it promotes strength gains while keeping body fat the same or even lowering it to prevent muscle loss while dieting. This advantage proves extremely advantageous for athletes in sports that have weight classes to improve performance, without the risk of being raised into a higher weight class. Masteron, an excellent cutting steroid, has recently become very popular in the underground market due to its efficacy and safety quotients compared to other steroids on sale.

Undoubtedly one of the most popular bodybuilding steroids of all time, Drostanolone Propionate has the ability to reduce estrogen in the body to a great extent. This steroid has a dramatic hardening effect on a lean physique and promotes greater metabolic activity and is most effective when used by athletes already in a lean state or when the level of body fat is already low. Masteron does not aromatize in the first place but may weaken the aromatase effect of many other anabolic steroids. Masteron inhibits water retention and athletes and bodybuilders using this drug can feel tight and very full after using it to experience "muscle pumps" like never before in the gym. In addition to these advantages, Masteron is also useful to accentuate fine details of muscles like striations.

The recommended dose of Masteron propionate for men is 500-700mg every week. This steroid is best stacked with Anadrol, Testosterone propionate, Dianabol, and Trenbolone acetate. This anabolic steroid may be stacked with Clenbuterol, Ephedrine, T3, Winstrol, and even Growth hormone or IGF-1. 

Masteron enanthate, which is also known as Drostanolone enanthate, has the chemical name of 17beta-Hydroxy-2alpha-methyl-5alpha-androstan-3-one Enanthate. This steroid has an active life of nearly eight to nine days and can be detected for up to several weeks. It has an anabolic androgenic rate of 62:25.

This steroid provides an aesthetic enhancement effect and is considered by bodybuilders as one of the best steroids to reduce any possible subcutaneous water retention that may obscure the view of muscle mass underneath. It also enhances bioavailability of other steroids in an anabolic steroid cycle through its anti-estrogen and anti-aromatase effects and preventing a measurable amount of SHBG (Sex Hormone Binding Globulin) from binding to other anabolic steroids and rendering them inactive. This anabolic androgenic steroid is best used for its ability to inhibit the transformation of free testosterone to estrogen and thereby enhancing the rate of free testosterone circulating in the body. The recommended dosage of Masteron enanthate is 400-600 mg weekly for men and 100 mg weekly for females and can be stacked with Trenbolone Enanthate, Clenbuterol, Ephedrine, T3, IGF-1, and Testosterone.

Masteron, available in oral and injectable forms, is not recommended to those suffering from health problems like testicular atrophy, testicular cancer, prostate cancer, breast cancer, liver damage, kidney damage, stroke, high blood pressure, and respiratory problems. The use of Masteron enanthate or propionate is also not advised for girls and women, especially who are pregnant, breastfeeding, or may get pregnant while using it. It is also not advised for children or those diagnosed with hypertension, high blood pressure, and prostate or breast cancer or those treated for health conditions such as testicular atrophy, testicular cancer, liver damage, kidney damage, stroke, and respiratory problems.

When abused or overdosed, Masteron can lead to oily skin, acne, body/facial hair growth, deepening of the voice, and hair loss. It may even cause increased sebum secretion (oily skin), increased bouts of acne (associated with increased sebum secretion), bodily and facial hair growth, and the increased risk of male pattern baldness. In women, Masteron can cause side effects like development of male secondary sex characteristics such as deepening of the voice, growth of body and facial hair), clitoral enlargement, and menstrual irregularities. Abuse of this steroid can even lead to suppression of the HPTA (Hypothalamic Pituitary Testicular Axis) and natural endogenous Testosterone production. Therefore, the use of post cycle therapy drugs like Clomid or Nolvadex is highly recommended to restore the normalization of the HPTA and endogenous Testosterone production as quickly as possible.

The Benefits of GP T3 by Geneza Pharmaceuticals

GP T3 (Trijodthyronin, Cytomel) is a thyroid hormone designed and developed to treat hypothyroidism. Hypothyroidism is simply a condition where adequate thyroid hormone(s) are not being produced, commonly this can be caused by an iodine deficiency, as well as pituitary malfunction among other causes but it is a condition that is quite common. Through the use of Cytomel we can increase the amount of thyroid hormones we have in our body, most notably the Triiodothyronine hormone commonly known as T3. The Triiodothyronine hormone is responsible for many functions, most notably metabolic activity but it also plays a role in bodily growth and the heart among many others. As T3 is produced by the pituitary gland its mode of action in terms of development and release is regulated by the thyroid-stimulating hormone (TSH.) Once thyroid hormones both T3 and T4 reach a certain level in the blood production is decreased as increased levels block TSH from being released, however, once the levels fall TSH is again released and more T3 and T4 is produced. By supplementing with Cytomel we actively increase the amount of T3 in our body far beyond what natural TSH will allow.

T3 is responsible for regulating the rate in-which energy is burned in terms of both nutrient intake, as well as stored energy. By introducing Cytomel into the body, a synthetic form of the T3 hormone we increase this rate, in very simple terms Cytomel or T3 feeds off of raw energy and as levels increase more energy is needed to meet its needs. This increase in energy feeding results in producing greater metabolic activity; as stored body-fat is stored energy it begins to burn at a faster rate as the amounts of the T3 hormone increase. However, it is important to note when T3 levels increase the energy demands must be met and they will be met one way or another. This simply means both fat and muscle tissue can be used as this energy source; while fat will be the primary focus, if adequate measures are not taken when consuming Cytomel muscle tissue will be burned as the Cytomel will get what it needs by any means possible and will not discriminate.


With a simple understanding of Cytomel and the T3 hormone understanding its benefits should come quite easily. By taking Cytomel we increase the amount of T3 in our body, by increasing the amount of T3 in our body we increase metabolic activity; by increasing metabolic activity we increase the rate in-which we burn fat. When we look at it in its most simplistic terms it is just that, rather simple; however, to fully understand the benefits of Cytomel we must understand the full effects of the T3 hormone which are quite vast and affect many various areas. While these affects are vast we are only largely concerned with how they affect metabolic activity, however, it’s effects can stretch to even the heart as increased levels of the T3 hormone increase cardiac output

By taking GP T3 (Cytomel) we greatly increase protein efficiency, however, we also increase the rate in-which protein is broken down. Due to this fact adequate amounts of protein must be taken in but this is good news as even though we require more than normal each gram is now being utilized to a far greater degree. Further and this is of the greatest importance, when we take GP T3 (Trijodthyronin, Cytomel) we increase the rate in-which glucose is metabolized by increasing the rate in-which glycogen is broken down. The faster this occurs the sooner the body is required to rely on stored body-fat for an energy source. Further and of equal importance, by taking GP T3 we increase the rate in-which cholesterol is broken down, all of these things greatly aid in increasing the rate of lipolysis.

The Side-Effects:
As is with all medications GP T3 (Cytomel) does carry with it potential negative side-effects, however many of the side-effects commonly associated with this medication are of little truth but some do exist. The blatant obvious negative effect is undoubtedly the loss of muscle tissue; as many performance enhancing athletes use Cytomel in an aid to lose body-fat they do so on a calorie restricted diet, because of this low consumption of calories, if adequate amounts are not in place muscle tissue will be burned. For this reason, a performance enhancing athlete will never take Cytomel without anabolic steroids, ignoring this rule will assuredly result in the loss of a vast amount of lean tissue. Beyond this possible negative side-effect others do exist but they prove to be very individualistic, dose dependent and in many cases very rare. Possible side-effects include most commonly, headaches, insomnia and excess sweating. Many women who use GP T3 (Trijodthyronin, Cytomel) may also find their menstrual cycles disrupted, however, this is often to be expected when body-fat becomes extremely low.
We have established that as a performance enhancing athlete GP T3 is to only be used in conjunction with anabolic steroids and never alone as use alone will in-fact result in a loss of muscle tissue. With this in mind the next question is when is the best time to use? It should go without saying that during cutting cycles such as a competitive bodybuilding cycle is the best time to use this medication and common practice is to use GP T3 the final 6 weeks of competition to get rid of that last bit of fat; however, it can be successfully used for the entire duration of a diet but one will need to keep an eye on tissue loss if this path is taken. For most a cycle of GP T3 (Cytomel) that is in the 6-8 week range will prove to be all the Cytomel they’ll ever need. As for the amounts, generally 25mcg per day is a good place to start with increases of 12.5mcg being applied as needed. This protocol includes Cytomel cycles for both men and women, however both will necessarily keep the dose as low as possible and only increase as needed. Most men can increase their dose safely to 150mcg per day while women will necessarily keep a maximum dose at 100mcg per day. In either case, learn to listen to your body, learn how to accurately observe your body and the effects and if you do you’ll find your Cytomel use to be more enjoyable and effective. There is a final note that will prove to provide a great benefit in thyroid recovery after use is discontinued, easing into recovery is far more beneficial. There is no need to gradually ramp down but rather simply drop your dose down to the original starting point of 25mcg every day and hold for approximately two weeks. By following this method you will ensure your thyroid begins production sooner than later.

The effect of Equipoise on the body of the athlete

Steroids (also known as cortisone or corticosteroids) are hormones that occur naturally in the body. Steroids decrease inflammation, suppress the body's immune system, block DNA from being made, as well as block a chemical called histamine (released during an allergic reaction). Steroid medicines are man-made but are similar to these natural hormones. The type of steroids used to treat disease are called corticosteroids. They are different to the anabolic steroids which some athletes and bodybuilders use. Anabolic steroids have very different effects. Steroids are available as tablets, soluble tablets and solutions, creams, ointments, inhalers, and injections.

Oral steroids are steroids that you can take by mouth - tablets, soluble tablets and liquids (solutions). Oral steroids available in the UK include: Betamethasone, Cortisone, Deflazacort, Dexamethasone, Hydrocortisone, Methylprednisolone, Prednisolone and Fludrocortisone acetate. They come in various different brand names. Prednisolone is the most commonly used oral steroid. This leaflet discusses the main possible side-effects of oral steroids as well as other important information if you take oral steroids. Oral steroids are used to treat a large number of conditions. Some examples include: inflammatory bowel diseases (for example, Crohn's disease, ulcerative colitis), autoimmune diseases (for example, autoimmune hepatitis), joint and muscle diseases (for example, rheumatoid arthritis, polymyalgia rheumatica), allergies and asthma. They are also used to treat some cancers. In addition they can be prescribed as replacement treatment for people who have stopped making their own steroids - Addison's disease.

Consider the effect of Equipoise:
Equipoise was actually created while attempting to make a product which would be be a long acting injectable Dianabol (Methandrostenolone). What was actually created was a product which, in the real world acts nothing like D-bol, despite its similarity to it chemically. A simple way to think of Equipoise, chemically at least, is simply as Dianabol without the 17-alpha-methyl group (thats the thing which makes D-bol able to be ingested orally and not be destroyed by your liver). To make Equipoise, a double bond was added between carbon atoms 1 and 2 of the Steran Nucleus of Testosterone. What does this mean? Well, first of all, since Equipoise was created by one simple modification in the testosterone molecule, you could rightly suspect that it shares many similarities with it. Equipoise is just as anabolic as testosterone (as you can tell by its anabolic rating above), but only half as androgenic.

Its not very common to compare Equipoise to testosterone, however a far more common comparison is between Equipoise and Deca. Equipoise doesn't actually act much like deca at all. Deca is actually a progestin and a 19-nor derived steroid whereas Equipoise is more closely related to testosterone (being only one double bond differ rent). Duchaine later rescinded his original statement on Equipoise and said that it was disappointing as a mass builder when compared with deca, but a far better drug than for both strength gains and vascularity. Unfortunately, the myth that Equipoise's action is similar to Deca's has persisted for nearly 2 decades after he revised his opinion, this is most evident on internet message boards today, where many will advise against including both of them in a cycle because "they act the same way."

The 1-2 double bond that Equipoise has is responsible for many of its characteristics. First of all, it acts to slow aromatization (conversion into estrogen). The best estimate is that it does so at roughly half the rate of testosterone. This is the best number Ive found in studies. Athletes almost never report estrogenic side effects with Equipoise, even when the dose is up to a gram per week. Virilization (development of male sexual characteristics in women) is almost never seen with this compound, when reasonable doses are used by female athletes. This is one of the few injectable compounds which could be successfully be used by female athletes and bodybuilders, and isn't often faked. That double bond is also responsible for Equipoises resistance for being changed by the 5- 5-Alpha-reductase enzyme. This enzyme converts a small amount of Boldenone into Dihydroboldenone, which is a very potent androgen (7x as anabolic as testosterone). Such a small amount of it is converted that its really of no concern to most athletes taking Equipoise. This factor, plus its low aromatization rate mean athletes don't need to consider using ancillaries with Equipoise.

Equipoise Side Effects:
One of the most pronounced effects in Equipoise is its ability to raise your RBCs (red blood cells). This is very typical of anabolic steroids; however, Equipoise would appear to do it to a slightly greater degree than most. One of the other effects most Equipoise users report is an increased appetite. Its because of this ability to increase appetite that many will include Equipoise in a mass cycle, and its for the quality of muscle gained on it that many will include it in a cutting cycle.

Deca Durabolin Effect in bodybuilding

This is an injectable steroid that is a derivative of 19-nortestosterone. It is one of the most popular steroids of all time. Deca is a low androgenic steroid, with high anabolic properties. It is used for developing size and strength. It does not have very high liver toxicity nor does it disturb the body’s own hormone functions too excessively at low doses. Deca Durabolin is a 19-Nor compound (some would say that it is the 19-nor compound), and as such, it shares basically the same characteristics with all of them. One thing unique to Deca, above nearly all steroids, is the mystique it has had for the last quarter of a century. On a personal level, Ive included Deca in cycles at doses ranging from 100mgs/week to 2,000mgs per week. For many, this was and is the final word on Deca. Lets delve into some of the reasons that Deca's mystique may be well deserved. Nandrolone is by far one of the most popular anabolic steroids available. This is due to the compound's affinity for being highly anabolic but relatively mild in terms of androgenic side effects. Nandrolone is the base steroid 19Nor-testosterone, meaning that it is like testosterone in appearance except for the absence of a carbon atom in the 19th position. This small change makes a major difference in the characteristics of the compound. Notably, this change makes Nandrolone a less potent agonist of the androgen receptor. This of course reduces the chance that a user will experience androgenic side effects. Instead of forming Dihydrotestosterone when encountering the 5 alpha reductase enzyme like testosterone does, Nandrolone will form dihydronandrolone. Dihydronandrolone is extremely mild in terms of it's antagonizing the androgen receptor. Therefore androgenic side effects should be far less likely to occur with Nandrolone than with testosterone. It is of note however that Nandrolone is believed to have some activity as a progestin in the body. Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. The compound will stimulate the progesterone receptor, along with progesterone. Side effects associated with this activity are similar to some of those related to estrogenic ones including water retention, acne, and gynecomastia among others. However these side effects are fairly rare in comparison to more androgenic compounds.

First of all, Deca Durabolin (and Nandrolone in general) doesn't produce many estrogenic or androgenic side effects. This is because Deca Durabolin has a very low rate of aromatization (conversion to estrogen via the aromatase enzyme), roughly equal to 20% the rate of Testosterone. Deca will aromatize in higher dosages, but not at the rate of testosterone’s or other high androgenic compounds. This drug can be used for cutting or for bulking. Athletes have stacked it with virtually every drug. It is a good base drug on any cycle. Deca is said to have the best effect to side effect ratio of any other steroid.

Women use this drug but only in very low dosages, 25mg per week. Deca has been established as a great soother of sore joints and tendons. Athletes report that sore shoulders, knees, and/or elbows are somehow without pain on the Deca cycle. This may be substantiated by proving it reduces the amount of cortisol getting into muscle tissue during the cycle. Deca also dramatically improves nitrogen retention and recuperation time between workouts. Deca has shown up positive on more steroid tests than any other steroid. This is due to the fact that so many athletes use it, and that it stays in the system at a detectable level for up to a year. The higher the fat content of the user, the longer it stays in your system. Deca can be active from 10-14 days after injection, but weekly injections of 300-600 mgs are common for men. Deca, or more precisely Nandrolone Decanoate, is commonly counterfeited.

Endocrine and Metabolic:
Endocrine side effects noted during exogenous administration of anabolic steroids have included inhibition of endogenous testosterone release by means of feedback inhibition of pituitary luteinizing hormone (LH). Large doses of exogenous anabolic steroids may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone (FSH). The androgenic activity of anabolic steroids may decrease levels of thyroid-binding globulin and result in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction.
Metabolic effects occurring during anabolic steroid therapy in immobilized patients or those with metastatic breast disease have included osteolytic-induced hyperglycemia. Anabolic steroids affect electrolyte balance, nitrogen retention, and urinary calcium excretion. Edema, with and without congestive heart failure, has occurred. Decreased glucose tolerance requiring adjustments in hyperglycemia control has been noted in diabetic patients. Significant increases in low density lipoproteins (LDL) and decreases in high density lipoproteins (HDL) have occurred.

Bodybuilders And Anabolic Steroids

Many competitive bodybuilders take anabolic steroids to achieve their freakishly exaggerated physiques. That is no secret. But steroids can be only one part of an extreme regimen that can wreak havoc on the body. Human growth hormone, supplements, painkillers and diuretics can also be used to create the “shrink-wrapped” muscles so prized in the aesthetic. And the high concentration of muscle mass puts stress on the body, as if the lifter were obese. Lifting weights in the gym is “extremely healthy for you,” said Kenneth Wheeler, a former elite bodybuilder known as Flex. “But if you want to be a bodybuilder and compete at the highest level, it has nothing to do with health.” A relatively rare form of kidney disease forced Wheeler to retire in 2003 at age 37, and he needed a kidney transplant later that year. Determining the extent of the damage that bodybuilders inflict on themselves is difficult, in part because there is little interest in financing studies on such an extreme group, and because bodybuilders are not always honest about what they take. That is why a case study published last month by a top kidney journal is generating interest in the nephrology and bodybuilding communities. It is among the first to assert a direct link between long-term steroid use and kidney disease. The study began 10 years ago when a kidney pathologist at Columbia University Medical Center in New York noticed that a bodybuilder had an advanced form of kidney disease. Curious, she started looking for similar cases and eventually studied 10 men with serious kidney damage who acknowledged using steroids. Nine were bodybuilders and one was a competitive power lifter with a similar training routine.

All 10 men in the case series, published in November by the Journal of the American Society of Nephrology, showed damage to the filters of the kidney. Nine had an irreversible disease known as focal segmental glomerulosclerosis — the same disease contracted by Wheeler — even though the men in the study did not have other apparent risk factors. Their disease was worse than in obese patients with a higher body-mass index, suggesting that steroids — combined with the other practices — might be harming the kidneys.  Bodybuilders and modern fitness models present physiques that make them look like aliens from outer space compared to the average person with a beer belly you meet on the street. They look quite powerful, strong, aesthetic and lean. Since the time of Arnold Schwarzenegger and before bodybuilding has been considered always a source of health and longevity. Many even consider it the fountain of youth. Unfortunately, behind the scenes the story is quite different and it seems that inside that muscular and lean body there’s often damaged hardware that can cause bugs in the future. There’s nothing wrong with exercising. Since the beginning of time exercising has been presented as a healthy activity that makes you a better version of yourself. What doesn’t kill you, makes you stronger, correct? This is one of the reasons why many people often refer to gyms as health clubs. They lift multiple plates on each side of the barbell and don’t fuck around with nonsense. Similar ego lifting is known to cause multiple injuries and it’s not uncommon for a bodybuilder to tear a few tendons during his career.

People like Branch Warren have become notorious for their poor training form. The idea behind Branch Warren’s style of lifting is simple: if the bar ain’t bending, you are just pretending.  If you put your ego to the side just for a little bit, you can avoid a lot of potential injuries. While exercising can obviously cause health problems it’s not what makes bodybuilding and fitness unhealthy. It’s actually the cause of the least amount of problems bodybuilders and fitness models experience. There is no doubt that steroids and other performance-enhancing drugs (PED) have been part of bodybuilding since the very beginning of the sport and they are the reason why bodybuilders keep getting bigger and bigger. It’s not that nutrition and training changes – it’s the syringe size and its content that increase and improve. Anabolic steroids are a huge part of a bodybuilder’s life. Most bodybuilders would rather have a coach experienced with drug protocols than somebody who knows how to train and eat correctly. This is not a surprise since no matter how well your training is, you will never reach the physical development of modern professionals unless you ‘juice’. If you don’t have somebody to tell you how to win the chemical war, you are doomed to fail in your pursuit of a super muscular body. In general, steroids are not as dangerous as people make them appear. They are medical products that in certain situations save people’s lives and help them get back on their feet. That’s one of the main reason why anabolic steroids are produced in the the first place. They are like morphine – it can help you or break you. The main reason why bodybuilders as well as modern fitness models experience health problems due to steroid abuse is the amount of different drugs they use. It’s not uncommon for a bodybuilder to be on a few grams of testosterone a week coupled with a large cocktail of other powerful muscle enlarging pills. Abuse of similar substances is known to cause liver, kidney and heart failure. There are also many minor side effects such as hair loss, testicular atrophy and reduction of natural testosterone production. Females are also seriously affected by anabolic steroids and after a certain point they start turning into men.

Deca Durabolin - Nandrolone Oil-Based Injection

In general, USA Deca Durabolin is probably the post popular, sought-after steroid. It is oil-based and comes in either 100-mg./ml or 200-mg/ml. injection. The drug is considered slow to convert to estrogen, a good mass and strength-builder and, for a variety of suggested chemical reasons (none really proven), it is considered to ease joint pain. However, it will suppress the pituitary-testosterone loop in due time. The USA pharmaceutical versions are hard to obtain. Lately, Some of the Mexican veterinary steroids (of all kinds) have tested poorly.  Deca-Durabolin is the Organon brand name for the injectable steroid Nandrolone Decanoate. This compound came around early in the wave of commercial steroid development, first being made available as a prescription medication in 1962. This steroid is an extremely long acting compound, with the Decanoate ester said to provide this drug a slow release time of up to three or four weeks. While perhaps true in a technical sense, what we find with further investigation is that the release parameters after a single injection are such that a strong release of Nandrolone is really only maintained for one to two weeks. This figure admittedly fails to take into account drug buildup that may occur after multiple injections, which may allow a longer duration of good effect to be seen. Figure 1 is provided to illustrate the release dynamics of a single 200mg injection. As you will see, by the end of the second week levels are already approaching baseline.

World Wide "Deca" is one of the most widely used anabolic steroids. Its popularity is due to the simple fact that it exhibits many very favorable properties. Structurally Nandrolone is very similar to testosterone, although it lacks a carbon atom at the 19t" position (hence its other name 19-nortestosterone). The resulting structure is a steroid that exhibits much weaker androgenic properties than testosterone. Of primary interest is the fact that Nandrolone will not break down to a more potent metabolite in androgen target tissuess. You may remember this is a significant problem with testosterone. Although Nandrolone does undergo reduction via the same (5-alpha reductase) enzyme that produces DHT from testosterone, the result in this case is dihydronandrolone. This metabolite is weaker than the parent Nandrolones, and is far less likely to cause unwanted androgenic side effects. Strong occurrences of oily skin, acne, body/facial hair growth and hair loss occur very rarely. It is however possible for androgenic activity to become apparent with this as any steroid, but with Nandrolone higher than normal doses are usually responsible.

Nandrolone also show an extremely lower tendency for estrogen conversion. For comparison, the rate has been estimated to be only about 20% of that seen with testosterones9. This is because while the liver can convert Nandrolone to estradiol, in other more active sites of steroid aromatization such as adipose tissue nandrolone is far less open to this process. Consequently estrogen related side effects are a much lower concern with this drug. An antiestrogen is likewise rarely needed with Deca, gynecomastia only a worry among sensitive individuals. At the same time water retention is not a usual concern. This effect can occur however, but is most often related to higher dosages. The addition of Proviron and/or Nolvadex should prove sufficient enough to significantly reduce any occurrence. Clearly Deca is a very safe choice among steroids. Actually, many consider it to be the best overall steroid for a man to use when weighing the side effects and results. It should also be noted that in HIV studies, Deca has been shown not only to be effective at safely bringing up the lean body weight of patient, but also to be beneficial to the immune system.

It is of note however that Nandrolone is believed to have some activity as a progestin in the body". Although progesterone is a c-19 steroid, removal of this group as in 19-norprogesterone creates a hormone with greater binding affinity for its corresponding receptor. Sharing this trait, many 19-nor anabolic steroids are shown to have some affinity for the progesterone receptor as well'2. This can lead to some progestin-like activity in the body, and may intensify related side effects. The side effects associated with progesterone are actually quite similar to those of estrogen, including negative feedback inhibition of testosterone production, enhanced rate of fat storage and possibly gynecomastia. Many believe the progestin activity of Deca notably contributes to suppression of testosterone synthesis, which can be marked despite a low tendency for estrogen conversion.

Deca is not known as a very "fast" builder. The muscle building effect of this drug is quite noticeable, but not dramatic. The slow onset and mild properties of this steroid therefore make it more suited for cycles with a longer duration. In general one can expect to gain muscle weight at about half the rate of that with an equal amount of testosterone. A cycle lasting eight to twelve weeks seems to make the most sense, expecting to elicit a slow, even gain of quality mass. Although active in the body for much longer, Deca is usually injected once per week. The dosage for men is usually in the range of 200-600mg. If looking to be specific, it is believed that Deca will exhibit its optimal effect (best gain/side effect ratio) at around 2mg per pound of body weight/weekly. Deca is also a popular steroid among female bodybuilders. They take a much lower dosage on average than men of course, usually around 50mg weekly. Although only slightly androgenic, women are occasionally confronted with virilization symptoms when taking this compound. Should this become a concern, the shorter acting nandrolone Durabolin would be a safer option. This drug stays active for only a few days, greatly reducing the impact of androgenic buildup if withdrawal were indicated.